2240s

2246

 * In October, the Enterprise was the first Federation ship to reach Tarsus IV with food and supplies for the famine-stricken colony; however, interference from the Klingon warship IKS Kut'luch delayed their arrival causing the execution of 4,000 colonists at the hands of Kodos the Executioner.

2249

 * The Enterprise welcomed back George Samuel Kirk Sr. and his 16-year-old son James T. Kirk, as the starship transported them to a newly discovered archaeological site on the planet Faramond.
 * The USS Challenger is commissioned.