- The USS Enterprise is commissioned under Robert April.
- The Prototype ship of the Red Dwarf-class Project USS Red Dwarf began construction.
- Michael Burnham begins attending the Vulcan Science Academy making her the first Human to do so.
- Pavel Chekov is born to Andrei Chekov in Russia, on Earth.
- The inconclusive Battle of Donatu V is fought between Federation and Klingon forces near Sherman's Planet.
- Emony Dax visits Earth to judge a gymnastics competition at the University of Mississippi, where she meets Leonard McCoy.
- Jonathan Archer dies at the age of 133.
- Doctor Tristan Adams begins to revolutionize and Humanize prisons and the treatment of prisoners by developing new methods to treat the criminally insane. Meanwhile, the Federation begins to convert a number of their penal colonies over to asylums to treat inmates, rather than to "cage" them up.
- An exotic fungus destroys most of planet Tarsus IV's food supply.
- In October, the USS Enterprise was the first Federation ship to reach Tarsus IV with food and supplies for the famine-stricken colony; however, interference from the Klingon warship IKS Kut'luch delayed their arrival causing the execution of 4,000 colonists at the hands of Kodos the Executioner.
- Hoshi Sato and her family die on Tarsus IV.
- The Enterprise welcomed back George Samuel Kirk Sr. and his 16-year-old son James T. Kirk, as the starship transported them to a newly discovered archaeological site on the planet Faramond.
- The USS Challenger is commissioned.
- Charles Evans is born.
- Tina Lawton is born.
- Joanna McCoy, daughter of Leonard McCoy, is born.
- Michael Burnham graduates from the Vulcan Science Academy and begins her seven-year service under Captain Philippa Georgiou.
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